Determining the Right Time for Antidepressant Discontinuation

Mental Health

Determining the Right Time for Antidepressant Discontinuation

Written by

Isha Team


September 7, 2023


October 6, 2023

Key Considerations for Stopping Antidepressants

Choosing when to discontinue antidepressant medication involves thoughtful evaluation. Here are significant factors to ponder:

1. Meeting Treatment Criteria

The CANMAT guidelines recommend antidepressant treatment for 6-9 months after symptom improvement for individuals with depressive disorders. For more severe cases, treatment up to 2 years post-improvement is suggested. These guidelines apply to anxiety disorders as well, often spanning 6 to 12 months.

2. Pregnancy and Breastfeeding

For women of childbearing age, discussing antidepressant use during pregnancy with healthcare providers is crucial. Some may consider tapering or using the lowest effective dose to limit fetal exposure.

3. Resolution of Original Symptoms

When the underlying factors causing depression or anxiety have improved, discontinuation becomes a consideration. The evolution of situations that initially led to these conditions may signal readiness for tapering.

4. Exploring Alternative Treatment

Certain treatment methods, like psychedelic therapy, may require discontinuing antidepressants due to potential interactions.

5. Unsatisfactory Outcomes

If an individual doesn't respond well to a particular antidepressant, switching to a different medication or alternative treatment could be explored.

6. Intolerable Side Effects

Unmanageable side effects may prompt a discussion about discontinuation, potentially followed by an alternative medication or treatment.

Factors to Weigh Before Tapering

Several crucial elements impact the decision to taper antidepressants:

✴️ Resiliency

Assess your ability to cope with stressors and adapt. Adequate psychological resilience is important during the tapering process.

✴️ Coping Strategies

Strong coping mechanisms are vital during tapering. Dependence on substances during stress suggests a need for building healthier coping skills.

✴️ Support

A robust support network enhances tapering success. Engage friends, family, and community groups for assistance during challenging times.

✴️ Situational Readiness

Tapering should coincide with a stable environment. Evaluate personal circumstances, relationships, and external factors before proceeding.

When Not to Consider Tapering

Certain scenarios aren't conducive to tapering:

❗ During Stressful Life Events

High-stress periods, such as divorce, job loss, or medical issues, can intensify withdrawal effects. Wait for stability before tapering.

❗ While Experiencing Symptoms

Tapering during ongoing depression or anxiety symptoms and benefiting from treatment may not be advisable. Continue until symptoms improve.

Self-Reflection: Is It Time for Tapering?

Self-awareness is key before making any decision. Consider these questions:

  • What led to medication initiation?
  • How have my circumstances changed since then?
  • Why do I want to discontinue medication?
  • What life changes do I envision post-discontinuation?
  • What benefits and drawbacks do I associate with my medication?
  • What fears or concerns do I have about tapering?
  • How do I typically cope with stress?
  • What support can I rely on during tapering?
  • On a scale of 1 to 10, how ready am I to begin the tapering journey?


  • Horowitz, M. A., & Taylor, D. (2019). Tapering of SSRI treatment to mitigate withdrawal symptoms. The Lancet Psychiatry, 6(6), 538–546.
  • Schuck, R. N., Pacanowski, M., Kim, S., Madabushi, R., & Zineh, I. (2019). Use of titration as a therapeutic individualization strategy: An Analysis of Food and Drug Administration–Approved Drugs. Clinical and Translational Science, 12(3), 236–239.
  • Haddad, P. M. (2001). Antidepressant discontinuation: A review of the literature. Journal of Clinical Psychiatry, 62(Suppl 12), 22-27.
  • Baldessarini, R. J., & Tarazi, F. I. (2005). Pharmacotherapy of depression. The Journal of Clinical Psychiatry, 66(Suppl 4), 5-12.

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