A lot of interesting papers this week including ketamine and zinc for anorexia nervosa, a meta-analysis comparing ketamine vs ECT, a clinical guideline for SI discussing ketamine. Read more below 👇
- A systematic review and meta-analysis compared the efficacy and adverse effects of ketamine versus electroconvulsive therapy for major depressive disorder, finding that ketamine seems to be an attractive alternative due to its rapid-onset antidepressant effects and impact on suicidal thoughts.
- Ketamine is a promising alternative to electroconvulsive therapy for major depressive disorder.
- Ketamine has rapid-onset antidepressant effects and an impact on suicidal thoughts.
- An article reviewed the potential benefits of novel ketamine and zinc treatment for anorexia nervosa, including potential beneficial interactions with the gut microbiome.
- Ketamine and zinc treatment could be a potential treatment for anorexia nervosa.
- There may be potential beneficial interactions with the gut microbiome.
- Clinical practice guidelines for management of suicidal behavior discussed the use of ketamine in rapidly reducing suicidal ideation.
- Ketamine has been shown to be effective in rapidly reducing suicidal ideation.
- The use of ketamine is recommended, but there are still some issues concerning its use.
- A review of psilocybin discussed its chemistry, clinical uses, and future research directions, along with other classic psychedelics like ketamine and LSD.
- Classic psychedelics like ketamine and psilocybin produce individualized subjective effects.
- There is a growing public interest in psychedelic medicine.
- An article studied the antidepressant effects of ketamine and how it triggers intracellular signaling pathways to mediate synaptic plasticity.
- Ketamine triggers intracellular signaling pathways to mediate synaptic plasticity.
- This mechanism underlies the rapid antidepressant effects and links to downstream signaling and the sustained effects.
- An article discussed the potential benefits of using an "active" placebo that mimics the cognitive effects of ketamine to optimize control conditions in studies comparing IV ketamine with a saline placebo.
- Using an "active" placebo may better mimic the cognitive effects of ketamine.
- This could optimize control conditions in studies comparing IV ketamine with a saline placebo.
- An article studied the effect of ketamine on endoplasmic reticulum stress in rats with neuropathic pain, finding an improvement in allodynia after ketamine injection.
- Ketamine injection improved allodynia in rats with neuropathic pain.
- The duration of the ketamine effect and changes in the contralateral and ipsilateral sides were observed.
- An article investigated the protective effect of Lipoxin A4 methyl ester on ketamine-induced neurotoxicity in SH-SY5Y cells, as well as morphological changes induced by ketamine.
- Lipoxin A4 methyl ester could protect against ketamine-caused cytotoxicity in SH-SY5Y cells.
- Inhibition of leptin signaling pathway may be involved in the protective effect.
- An article investigated the long-term effects of repeated exposure to various doses of ketamine on anxiety-like behaviors and locomotor activity in juvenile rats.
- The potential adverse effects of ketamine use in juvenile age are uncertain.
- Repeated exposure to various doses of ketamine could affect anxiety-like behaviors and locomotor activity in juvenile rats.
- An article studied the antidepressant effects of ketamine in mice treated with tumor necrosis factor-α, finding that BNIP3L/NIX-mediated mitophagy was involved in the antidepressant effects of ketamine.
- BNIP3L/NIX-mediated mitophagy is involved in the antidepressant effects of ketamine.
- Ketamine could alleviate passive stress-coping behaviors induced by tumor necrosis factor-α.
References:
- Moreira, D.A.S., Gauer, L.E., Teixeira, G., da Silva, A.C., Farias, L.P., & von Werne Baes, C. (2023). Efficacy and adverse effects of ketamine versus electroconvulsive therapy for major depressive disorder: A systematic review and meta-analysis. Journal of Affective Disorders.
- Elwyn, R., Mitchell, J., Kohn, M.R., Driver, C., Hay, P., & Walsh, B.T. (2023). Novel Ketamine and Zinc Treatment for Anorexia Nervosa and the Potential Beneficial Interactions With the Gut Microbiome. Neuroscience & Biobehavioral Reviews.
- Sarkhel, S., Vijayakumar, V., & Vijayakumar, L. (2023). Clinical practice guidelines for management of suicidal behaviour. Indian Journal of Psychiatry.
- Milliken, E., Galettis, P., & Martin, J. (2023). A review of psilocybin: chemistry, clinical uses and future research directions. Australian Journal of Chemistry.
- Kim, J.W., Suzuki, K., Kavalali, E.T., & Monteggia, L.M. (2023). Bridging rapid and sustained antidepressant effects of ketamine. Trends in Molecular Medicine.
- Feeney, A., & Papakostas, G.I. (2023). Pharmacotherapy: Ketamine and Esketamine. Psychiatric Clinics.
- Seo, E.H., Piao, L., Cho, E.H., Hong, S.W., & Kim, S.H. (2023). The Effect of Ketamine on Endoplasmic Reticulum Stress in Rats with Neuropathic Pain. International Journal of Molecular Sciences.
- Zhang, R., Wang, X., Xie, Z., Cao, T., Jiang, S., & Huang, L. (2023). Lipoxin A4 methyl ester attenuated ketamine-induced neurotoxicity in SH-SY5Y cells via regulating leptin pathway. Toxicology in Vitro.
- Arpacı, A.H., Çalıskan, H., Gunes, E., & Işık, B. (2023). Effects of the Recurrent and Different Doses of Ketamine Exposure on Anxiety-like Behaviors and Locomotor Activity in Juvenile Rats. Current Alzheimer Research.
- Lu, J.J., Wu, P.F., He, J.G., Li, Y.K., Long, L.H., Yao, X.P., & Yang, J.H. (2023). BNIP3L/NIX-mediated mitophagy alleviates passive stress-coping behaviors induced by tumor necrosis factor-α. Molecular Psychiatry.
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