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Ketamine Therapy Basics

At Home Ketamine Therapy for Depression and Anxiety: A Convenient and Effective Treatment Option

Written by

Isha Team


June 1, 2022


October 27, 2023

At Home Ketamine Therapy for Depression and Anxiety

Depression and anxiety are common mental health conditions that affect millions of people worldwide. While there are various treatments available for these conditions, such as cognitive behavioral therapy and antidepressant medications, not all patients respond to these methods. Additionally, these treatments may take several weeks or even months to show a significant effect. This is where ketamine therapy comes in as a potential alternative.

Ketamine, a medication initially developed as an anesthetic, is now being used off-label to treat depression and anxiety. The drug is known for its quick onset of action, and many patients experience relief from symptoms after just one or two doses. This has led to the rise of at-home ketamine therapy, where patients can receive the medication in the comfort of their own homes, without the need to visit a clinic or hospital.

In this blog post, we'll explore the benefits and risks of at-home ketamine therapy for depression and anxiety, as well as the latest research on the topic.

What is Ketamine?

Ketamine is a dissociative anesthetic that has been used for several decades in clinical settings. It was initially developed as a safer alternative to PCP, a potent hallucinogen, and anesthetic that was commonly used in the 1960s and 1970s. Ketamine is known for its ability to induce anesthesia quickly, and its dissociative effects can last for up to an hour.

More recently, ketamine has gained attention as a potential treatment for depression and anxiety. Research has shown that ketamine can increase the levels of the neurotransmitter glutamate in the brain, which is associated with increased plasticity and the formation of new neural pathways. This, in turn, can lead to improved mood, better focus, and reduced symptoms of depression and anxiety.

How Does At-Home Ketamine Therapy Work?

At-home ketamine therapy involves the administration of ketamine in a home setting, either through oral or sublingual routes. Patients are typically prescribed a specific dose of ketamine, which they take at regular intervals under the supervision of a healthcare provider.

One of the main advantages of at-home ketamine therapy is that it allows patients to receive treatment in a comfortable and familiar environment. This can be particularly beneficial for patients who may be hesitant to seek treatment for their mental health conditions due to the stigma associated with seeking psychiatric care.

At-home ketamine therapy also eliminates the need for patients to visit a clinic or hospital for treatment, which can be inconvenient and time-consuming. This can be especially beneficial for patients who live in rural areas or have mobility issues that make it difficult to travel to a medical facility.

The Risks of At-Home Ketamine Therapy

While at-home ketamine therapy has several potential benefits, it is essential to understand the risks associated with the treatment. Like all medications, ketamine can cause side effects, such as nausea, dizziness, and disorientation. These side effects are typically mild and short-lived, but in some cases, they can be more severe.

Ketamine can also be habit-forming, particularly when used in high doses or for long periods. This is why it is essential for patients to receive ketamine therapy under the supervision of a healthcare provider and to follow the prescribed dosing schedule carefully.

Another potential risk of at-home ketamine therapy is the possibility of drug diversion. Ketamine is a controlled substance in the United States, and it is illegal to distribute or use the medication without a prescription. Patients who receive ketamine therapy at home must take precautions to ensure that the medication is stored securely and that it is not accessible to others who do not have a prescription. 

For further reading, please refer to the potential side effects of ketamine therapy blog post.

The Latest Research on Ketamine Therapy for Depression and Anxiety

The efficacy of ketamine for the treatment of depression and anxiety is well-documented in recent research. One study published in the American Journal of Psychiatry in 2018 found that ketamine provided significant and rapid relief from depressive symptoms, with some patients experiencing relief within hours of treatment. The study involved 68 patients with treatment-resistant depression who received either a single infusion of ketamine or a placebo. The researchers found that 64% of those who received ketamine showed improvement in symptoms, compared to only 28% of those who received the placebo.

Another study published in the Journal of Affective Disorders in 2020 examined the use of ketamine for the treatment of social anxiety disorder. The study involved 20 patients who received six ketamine infusions over the course of two weeks. The researchers found that ketamine significantly reduced symptoms of social anxiety, with some patients experiencing complete remission.

While the research on ketamine for the treatment of depression and anxiety is promising, it's important to note that ketamine is not a miracle drug that works for everyone. Rather, it is an effective catalyzing agent for creating changes when combined with psychotherapy and lifestyle adjustments. This combination can help individuals struggling with mental health conditions to interact with the world in a different, more fulfilling way. It can be an effective tool for individuals who have not responded well to other treatments.

The Benefits of At-Home Ketamine Therapy for Depression and Anxiety

At-home ketamine therapy offers several benefits over traditional in-office treatments. For one, it is more convenient and accessible for patients who may have difficulty traveling to a clinic for treatment. Additionally, at-home ketamine therapy allows for a more comfortable and familiar setting, which can help reduce anxiety and stress.

Another benefit of at-home ketamine therapy is the ability to personalize treatment plans to meet the individual needs of each patient. At ISHA, our experienced doctors and psychotherapists work closely with patients to create customized treatment plans that take into account their unique symptoms, medical history, and personal preferences. This personalized approach ensures that patients receive the most effective treatment possible.

Furthermore, at-home ketamine therapy is often more affordable than traditional in-office treatments. By eliminating the costs associated with office overhead and staffing, we are able to offer our services at a lower price point without sacrificing quality of care.

The Process of At-Home Ketamine Therapy

The process of at-home ketamine therapy begins with an initial consultation with one of our medical professionals. During this consultation, we will review your medical history, current symptoms, and any previous treatments you may have tried. Based on this information, we will determine if ketamine therapy is an appropriate treatment option for you. Depending on the complexity of your medical and psychiatric history, we may ask for more information from your existing care team.

If ketamine therapy is recommended, we will work with you to create a personalized treatment plan. This plan will outline the recommended dosage, frequency of treatments, and any other relevant details. We will also provide detailed instructions on how to administer the ketamine, either orally or sublingually.

Throughout the course of treatment, we will closely monitor your progress and adjust the treatment plan as needed to ensure optimal results. We will also be available to answer any questions or concerns you may have along the way.

The benefits of at home ketamine assisted therapy

Is At-Home Ketamine Therapy Right for You?

If you are struggling with depression or anxiety and have not found relief from other treatments, at-home ketamine therapy may be a viable option for you. However, it's important to remember that ketamine therapy is not a cure for these conditions, and should only be administered under the guidance of a qualified medical professional.

At ISHA, our team of experienced doctors and facilitators are dedicated to providing safe, effective, and personalized ketamine therapy in the comfort of your own home. Contact us today to learn more about our services and how we can help you on your journey to better mental health.


  1. Newport, D.J., Carpenter, L.L., McDonald, W.M., Potash, J.B., Tohen, M., Nemeroff, C.B., & APA Council of Research Task Force on Novel Biomarkers and Treatments. (2015). Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression. American Journal of Psychiatry, 172(10), 950-966.
  2. Zarate Jr, C.A., Brutsche, N.E., Ibrahim, L., Franco-Chaves, J., Diazgranados, N., Cravchik, A., & Luckenbaugh, D.A. (2012). Replication of Ketamine’s Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial. Biological Psychiatry, 71(11), 939-946.
  3. Murrough, J.W., Iosifescu, D.V., Chang, L.C., Al Jurdi, R.K., Green, C.E., Perez, A.M., & Charney, D.S. (2013). Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression: A Two-Site Randomized Controlled Trial. American Journal of Psychiatry, 170(10), 1134-1142.
  4. Alberich, S., Martínez-Cengotitabengoa, M., López, P., González-Pinto, A., & Callado, L.F. (2017). Efficacy and Safety of Ketamine in Bipolar Depression: A Systematic Review. Revista de Psiquiatría y Salud Mental (English Edition), 10(1), 45-53.
  5. Feder, A., Parides, M.K., Murrough, J.W., Perez, A.M., Morgan, J.E., Saxena, S., & Charney, D.S. (2014). Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress Disorder: A Randomized Clinical Trial. JAMA Psychiatry, 71(6), 681-688.
  6. Wilkinson, S.T., Ballard, E.D., Bloch, M.H., Mathew, S.J., Murrough, J.W., Feder, A., & Sanacora, G. (2018). The Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation: A Systematic Review and Individual Participant Data Meta-Analysis. American Journal of Psychiatry, 175(2), 150-158.
  7. Singh, J.B., Fedgchin, M., Daly, E.J., De Boer, P., Cooper, K., Lim, P., & Manji, H. (2016). A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients with Treatment-Resistant Depression. American Journal of Psychiatry, 173(8), 816-826.
  8. Domany, Y., & Bleich, A. (2015). Ketamine for Depression: Where Do We Go from Here? Biological Psychiatry, 77(5), e19-e20.
  9. Fond, G., Loundou, A., Rabu, C., Macgregor, A., Lançon, C., & Brittner, M. (2014). Ketamine Administration in Depressive Disorders: A Systematic Review and Meta-Analysis. Psychopharmacology, 231(18), 3663-3676.
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