Vitamin B for Depression, Anxiety, and PTSD: Insights from Recent Studies

Mental Health

Vitamin B for Depression, Anxiety, and PTSD: Insights from Recent Studies

Written by

Isha Team


March 29, 2024


April 19, 2024

Vitamin B, known for its crucial role in maintaining physical health, also shows promise in the management of mental health disorders such as depression, anxiety, and PTSD. Let's dive into what recent scientific studies say about this important nutrient:

Basic Science Studies & Mechanism of Action

  • Vitamin B plays a significant role in brain health and functioning, influencing memory, cognitive impairment, and even psychiatric disorders. Particularly, vitamins B1, B3, B6, B9, and B12 are essential for neuronal function, with deficiencies linked to depression (Mikkelsen, Stojanovska, & Apostolopoulos, 2016).

Animal Studies

  • In mice models, vitamin B6, when combined with certain antidepressants, showed a reduction in depression and obsessive-compulsive behaviors, suggesting its role in enhancing antidepressant efficacy (Mesripour, Hajhashemi, & Kuchak, 2017).

Human Studies & Efficacy

  • Depression: A systematic review found that B vitamin supplementation, particularly in older adults with major depression, enhanced and sustained antidepressant response over one year (Ford, Almeida, Flicker, Hirani, McCaul, & Singh, 2015).
  • Anxiety: Studies indicate a potential benefit of vitamin B in reducing anxiety symptoms, though results are more prominent when combined with magnesium (Noah, Dye, Bois De Fer, Mazur, Pickering, & Pouteau, 2021).
  • PTSD: The evidence directly linking vitamin B supplementation with PTSD treatment is less clear. However, its role in overall mood stabilization may suggest potential benefits.

Dosage in Studies

  • Dosages vary across studies, but typical supplements include 0.5 mg of vitamin B12, 2 mg of folic acid, and 25 mg of vitamin B6. These dosages have been observed to have a beneficial impact, especially when combined with standard antidepressant treatments (Almeida et al., 2014).


While further research is needed to fully understand the impact of vitamin B on mental health disorders, existing studies suggest a beneficial role, especially in managing depression and anxiety symptoms. It's important to consider these findings in the context of overall health and treatment plans

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