Ketamine Therapy Blog — Mental Health Insights & Treatment Guides

Expert insights on ketamine therapy, depression, anxiety, PTSD, and mental health treatment — updated regularly by the Isha Health clinical team.

11,000 Patients: At-Home Ketamine Depression Data

Apr 29, 2026Research

Mathai et al. 2024 published real-world data from 11,441 at-home telehealth ketamine patients in the Journal of Affective Disorders. Here are the response rates, adverse events, and what it means for at-home treatment.

Esketamine Prevents Postpartum Depression: Meta-Analysis

Apr 29, 2026Research

A 2025 BMC Pregnancy and Childbirth meta-analysis finds perioperative esketamine during C-section significantly reduces postpartum depression incidence. Here is what the prevention data shows.

KARMA-Dep 2: Serial Ketamine Infusions for Inpatient Depression

Apr 29, 2026Research

The KARMA-Dep 2 trial published in JAMA Psychiatry tested serial ketamine infusions as adjunctive therapy for inpatient depression. Here is what the results mean for treatment-resistant depression care.

Ketamine-Enhanced Prolonged Exposure for PTSD

Apr 29, 2026Research

A 2024 RCT protocol explores ketamine-enhanced prolonged exposure therapy for veterans with PTSD. Here is how combining ketamine with PE may improve trauma processing outcomes.

The Neuroplasticity Window: What to Do After Ketamine

Apr 29, 2026Ketamine Therapy Basics

Ketamine triggers a 24-72 hour neuroplasticity window through BDNF release. Here is a practical guide to maximizing this window for lasting mental health improvement.

Ketamine for CRPS: A Case of Long-Term Pain Relief

Apr 26, 2026Research

A 2026 BMJ case report documents long-term relief of CRPS-associated limb dystonia with ketamine infusion. What this means for chronic pain patients.

The Montreal Model: Ketamine Therapy for Alcohol + Depression

Apr 24, 2026Research

A 2026 feasibility trial protocol combines structured ketamine therapy with psychotherapy for alcohol use disorder and treatment-resistant depression.

Group Ketamine Therapy for Identity-Based Trauma

Apr 23, 2026Research

A 2026 pilot study tested group ketamine-assisted psychotherapy for transgender adults experiencing identity-based trauma. Results showed significant improvements.

White House Accelerates Psychedelic Therapy for Serious Mental Illness: April 2026 Executive Order Explained

Apr 23, 2026Isha Team

A physician's read on the April 2026 White House executive order accelerating psychedelic therapy for serious mental illness — what changes, what doesn't, and what it means for patients today.

Trauma-Informed Care During Ketamine Treatment

Apr 22, 2026For Clinicians

Patients referred for ketamine therapy often have complex trauma histories. A 2026 clinical protocol outlines trauma-informed nursing practices for safe, effective treatment.

Ketamine and Your Gut: The Microbiome Connection

Apr 21, 2026Research

New research reveals a bidirectional relationship between ketamine and the gut microbiome. How gut bacteria may influence ketamine's antidepressant effects.

Ketamine for Depression in Older Adults with MCI

Apr 20, 2026Research

Can ketamine treat depression in older adults with mild cognitive impairment? A 2026 editorial in the American Journal of Geriatric Psychiatry examines the evidence.

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