Ketamine Therapy Blog — Mental Health Insights & Treatment Guides
Expert insights on ketamine therapy, depression, anxiety, PTSD, and mental health treatment — updated regularly by the Isha Health clinical team.
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Is Ketamine Safe During Pregnancy?
A 2026 PMC review and 2024 pregnancy safeguards study examine ketamine safety in perinatal mental health. Here is what the data says about risks, precautions, and the current clinical consensus.
Ketamine for Veterans: What the Research Shows
A 2024 meta-analysis and 2026 retrospective report examine ketamine therapy for veterans with PTSD and depression. Here is what the research shows about sublingual ketamine and intensive outpatient programs for military populations.
Combining Psychotherapy with Ketamine: The Evidence
A 2025 MDPI review examines the effects of psychotherapy on single and repeated ketamine infusions. Here is what the evidence says about combining molecular and psychological treatments.
Using Aroma to Optimize Your Ketamine Session: The Science of Set, Setting, and Smell
Scent has the most direct biological line to the brain regions ketamine acts on. A practical, evidence-grounded guide to using aroma to optimize set, setting, and integration.
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The Montreal Model: Longer-Lasting Depression Relief
McGill University's Montreal Model clinical trial showed a 30% depression score drop sustained for 8+ weeks when combining ketamine with psychotherapy. Here is what the sustained relief findings mean.
Ketamine vs ECT: Head-to-Head Trial Results
A 2024 secondary analysis in JAMA Network Open compared ketamine to ECT for treatment-resistant depression. Here is what the head-to-head trial data revealed about efficacy, side effects, and cognitive outcomes.
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11,000 Patients: At-Home Ketamine Depression Data
Mathai et al. 2024 published real-world data from 11,441 at-home telehealth ketamine patients in the Journal of Affective Disorders. Here are the response rates, adverse events, and what it means for at-home treatment.
Esketamine Prevents Postpartum Depression: Meta-Analysis
A 2025 BMC Pregnancy and Childbirth meta-analysis finds perioperative esketamine during C-section significantly reduces postpartum depression incidence. Here is what the prevention data shows.
KARMA-Dep 2: Serial Ketamine Infusions for Inpatient Depression
The KARMA-Dep 2 trial published in JAMA Psychiatry tested serial ketamine infusions as adjunctive therapy for inpatient depression. Here is what the results mean for treatment-resistant depression care.
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Ketamine-Enhanced Prolonged Exposure for PTSD
A 2024 RCT protocol explores ketamine-enhanced prolonged exposure therapy for veterans with PTSD. Here is how combining ketamine with PE may improve trauma processing outcomes.
The Neuroplasticity Window: What to Do After Ketamine
Ketamine triggers a 24-72 hour neuroplasticity window through BDNF release. Here is a practical guide to maximizing this window for lasting mental health improvement.
Ketamine for CRPS: A Case of Long-Term Pain Relief
A 2026 BMJ case report documents long-term relief of CRPS-associated limb dystonia with ketamine infusion. What this means for chronic pain patients.
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